Rate differences between first and second primary cancers may outline immune dysfunction as a key risk factor.
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ABSTRACT:
SUBMITTER: Zheng G
PROVIDER: S-EPMC7643639 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
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Rate differences between first and second primary cancers may outline immune dysfunction as a key risk factor.
Zheng Guoqiao G Sundquist Kristina K Sundquist Jan J Försti Asta A Hemminki Akseli A Hemminki Kari K
Cancer medicine 20200922 21
<h4>Background</h4>Many cancers are increased in immunosuppressed patients and evidence is accumulating that immune dysfunction may be a contributing risk factor for second primary cancers (SPCs). The aim of this study was to explore the potential influence of immune mechanisms in SPC.<h4>Methods</h4>We used the Swedish Cancer Registry (1990-2015) to select 13 male and 14 female first primary cancers (FPCs) that are known to be related to immune suppression. We assessed relative risks (RRs) for ...[more]
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