Unknown

Dataset Information

0

Human T cell glycosylation and implications on immune therapy for cancer.


ABSTRACT: Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome. When focusing on immunity, glycans are indispensable in virtually all signaling and cell-cell interactions. More specifically, glycans have been shown to regulate key pathophysiological steps within T cell biology such as T cell development, thymocyte selection, T cell activity and signaling as well as T cell differentiation and proliferation. They are of major importance in determining the interaction of human T cells with tumor cells. In this review, we will describe the role of glycosylation of human T cells in more depth, elaborate on the importance of glycosylation in the interaction of human T cells with tumor cells and discuss the potential of cancer immunotherapies that are based on manipulating the glycome functions at the tumor immune interface. 1,2.

SUBMITTER: De Bousser E 

PROVIDER: S-EPMC7644206 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC4133139 | biostudies-literature
| S-EPMC2279154 | biostudies-other
| S-EPMC8147841 | biostudies-literature
| S-EPMC4089009 | biostudies-literature
| S-EPMC5414870 | biostudies-literature
| S-EPMC4227513 | biostudies-literature
| S-EPMC5332936 | biostudies-literature
| S-EPMC5994506 | biostudies-literature
| S-EPMC140134 | biostudies-literature
| S-EPMC8082152 | biostudies-literature