Dataset Information

Efficacy of a Lactobacillus-Based Teat Spray on Udder Health in Lactating Dairy Cows.

ABSTRACT: Teat disinfection is a common pre- and post-milking mastitis prevention practice that is part of a mastitis control program in dairy herds. Commercially available teat disinfectants are generally chemical-based products. The use of these products has occasionally raised concerns about the risk of chemical residues in milk. An alternative treatment or prevention strategy based on probiotics has the potential to circumvent this risk. Two treatments were compared in a cross-over clinical trial in a single herd: a lactobacillus-based, post-milking teat spray (LACT), and a commercial iodine-based post-milking teat disinfectant product as (positive control, PC). The effect of the two treatments on cow somatic cell counts was quantified using a multivariate mixed-effects linear regression model with cow fitted as a random effect. The odds of teat end scores increasing from a low to a high score tended to be lower (OR = 0.74, 95% CI 0.54-1.01, P = 0.06) for cows receiving LACT treatment. On average, there was also a tendency for a lower somatic cell counts in the LACT treated cows (antilog of coefficient = 0.91, 95% CI 0.80-1.03, P = 0.13) compared with the PC treated cows. The application of the lactobacillus-based product to teats could reduce the rate of teat end scores progression from low to higher scores, and potentially improve teat end sphincter functions and udder health. Further, larger scale validation work is required to support the findings of the current study.

SUBMITTER: Alawneh JI

PROVIDER: S-EPMC7644449 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Efficacy of a Lactobacillus-Based Teat Spray on Udder Health in Lactating Dairy Cows.

Alawneh John I JI James Ameh S AS Phillips Nancy N Fraser Brandon B Jury Karen K Soust Martin M Olchowy Timothy W J TWJ

Frontiers in veterinary science 20201023

Teat disinfection is a common pre- and post-milking mastitis prevention practice that is part of a mastitis control program in dairy herds. Commercially available teat disinfectants are generally chemical-based products. The use of these products has occasionally raised concerns about the risk of chemical residues in milk. An alternative treatment or prevention strategy based on probiotics has the potential to circumvent this risk. Two treatments were compared in a cross-over clinical trial in a ...[more]

PMID: 33195609

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Project description:BackgroundOver the last years, genome-wide association studies (GWAS) based on imputed whole-genome sequences (WGS) have been used to detect quantitative trait loci (QTL) and highlight candidate genes for important traits. However, in general this approach does not allow to validate the effects of candidate mutations or determine if they are truly causative for the trait(s) in question. To address these questions, we applied a two-step, within-breed GWAS approach on 15 traits (5 linked with milk production, 2 with udder health, and 8 with udder morphology) in Montbéliarde (MON), Normande (NOR), and Holstein (HOL) cattle. We detected the most-promising candidate variants (CV) using imputed WGS of 2515 MON, 2203 NOR, and 6321 HOL bulls, and validated their effects in three younger populations of 23,926 MON, 9400 NOR, and 51,977 HOL cows.ResultsBull sequence-based GWAS detected 84 QTL: 13, 10, and 30 for milk production traits; 3, 0, and 2 for somatic cell score (SCS); and 8, 2 and 16 for udder morphology traits, in MON, NOR, and HOL respectively. Five genomic regions with effects on milk production traits were shared among the three breeds whereas six (2 for production and 4 for udder morphology and health traits) had effects in two breeds. In 80 of these QTL, 855 CV were highlighted based on the significance of their effects and functional annotation. The subsequent GWAS on MON, NOR, and HOL cows validated 8, 9, and 23 QTL for production traits; 0, 0, and 1 for SCS; and 4, 1, and 8 for udder morphology traits, respectively. In 47 of the 54 confirmed QTL, the CV identified in bulls had more significant effects than single nucleotide polymorphisms (SNPs) from the standard 50K chip. The best CV for each validated QTL was located in a gene that was functionally related to production (36 QTL) or udder (9 QTL) traits.ConclusionsUsing this two-step GWAS approach, we identified and validated 54 QTL that included CV mostly located within functional candidate genes and explained up to 6.3% (udder traits) and 37% (production traits) of the genetic variance of economically important dairy traits. These CV are now included in the chip used to evaluate French dairy cattle and can be integrated into routine genomic evaluation.

Dataset Information

Efficacy of a Lactobacillus-Based Teat Spray on Udder Health in Lactating Dairy Cows.

Publications

Efficacy of a Lactobacillus-Based Teat Spray on Udder Health in Lactating Dairy Cows.

Similar Datasets

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