Ontology highlight
ABSTRACT:
SUBMITTER: Fromm SA
PROVIDER: S-EPMC7644641 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Fromm Simon A SA Lawrence Rosalie E RE Hurley James H JH
Nature structural & molecular biology 20200831 11
The Rag GTPases (Rags) recruit mTORC1 to the lysosomal membrane in response to nutrients, where it is then activated in response to energy and growth factor availability. The lysosomal folliculin (FLCN) complex (LFC) consists of the inactive Rag dimer, the pentameric scaffold Ragulator, and the FLCN:FNIP2 (FLCN-interacting protein 2) GTPase activating protein (GAP) complex, and prevents Rag dimer activation during amino acid starvation. How the LFC is disassembled upon amino acid refeeding is an ...[more]