Ontology highlight
ABSTRACT:
SUBMITTER: Xia M
PROVIDER: S-EPMC7644669 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Xia Meng M Li Xuena X Diao Yao Y Du Bulin B Li Yaming Y
Translational oncology 20201101 1
Regulated by the tumor microenvironment, the metabolic network of the tumor is reprogrammed, driven by oncogenes and tumor suppressor genes. The metabolic phenotype of tumors of different driven-genes and different tissue types is extremely heterogeneous. KRAS-mutant non-small cell lung cancer (NSCLC) has glutamine dependence. In this study, we demonstrated that glutamine utilization of KRAS-mutant NSCLC was higher than that of KRAS wild-type. CB839, an efficient glutaminase inhibitor, synergize ...[more]