Ontology highlight
ABSTRACT:
SUBMITTER: Beknazarov N
PROVIDER: S-EPMC7644757 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Beknazarov Nazar N Jin Seungmin S Poptsova Maria M
Scientific reports 20201105 1
Computational methods to predict Z-DNA regions are in high demand to understand the functional role of Z-DNA. The previous state-of-the-art method Z-Hunt is based on statistical mechanical and energy considerations about B- to Z-DNA transition using sequence information. Z-DNA CHiP-seq experiment results showed little overlap with Z-Hunt predictions implying that sequence information only is not sufficient to explain emergence of Z-DNA at different genomic locations. Adding epigenetic and other ...[more]