Ontology highlight
ABSTRACT:
SUBMITTER: Lin L
PROVIDER: S-EPMC7645039 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Lin Lehang L Cheng Xu X Yin Dong D
Frontiers in oncology 20201023
Almost all cancer cells possess multiple epigenetic abnormalities, which cooperate with genetic alterations to enable the acquisition of cancer hallmarks during tumorigenesis. As the most frequently found epigenetic change in human cancers, aberrant DNA methylation manifests at two major forms: global genomic DNA hypomethylation and locus-specific promoter region hypermethylation. It has been recognized as a critical contributor to esophageal squamous cell carcinoma (ESCC) malignant transformati ...[more]