Identification of prognostic immune genes in laryngeal cancer.

ABSTRACT:

Objective

In this study, we aimed to identify prognostic immune-related genes and establish a prognostic model for laryngeal cancer based on these genes.

Methods

Transcriptome profiles and clinical data of patients with laryngeal cancer were downloaded from The Cancer Genome Atlas database. Integrated bioinformatics analyses were performed to identify genes associated with prognosis.

Results

Thirty prognostic immune-related genes for laryngeal cancer were identified. We constructed a regulatory network of prognosis comprising transcription factors and immune-related genes. Multivariate Cox regression analyses identified 15 immune-related genes in the network that were used to establish the prognostic model. The model exhibited excellent prognostic prediction ability w

SUBMITTER: Xiao H 

PROVIDER: S-EPMC7645519 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature