Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID-19 pneumonia.

ABSTRACT: In patients infected by SARS-CoV-2 who experience an exaggerated inflammation leading to pneumonia, monocytes likely play a major role but have received poor attention. Thus, we analyzed peripheral blood monocytes from patients with COVID-19 pneumonia and found that these cells show signs of altered bioenergetics and mitochondrial dysfunction, had a reduced basal and maximal respiration, reduced spare respiratory capacity, and decreased proton leak. Basal extracellular acidification rate was also diminished, suggesting reduced capability to perform aerobic glycolysis. Although COVID-19 monocytes had a reduced ability to perform oxidative burst, they were still capable of producing TNF and IFN-γ in vitro. A significantly high amount of monocytes had depolarized mitochondria and abnormal mit

SUBMITTER: Gibellini L 

PROVIDER: S-EPMC7645870 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature