Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC7646116 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Liu Zongtao Z Wang Yixuan Y Shi Jiawei J Chen Si S Xu Li L Li Fei F Dong Nianguo N
International journal of medical sciences 20201020 18
<b>Objectives</b>: This study amied to whether IL-21 promotes osteoblast transdifferentiation of cultured human Valvular interstitial cells (VICs). <b>Methods</b>: We first confirmed that IL-21 alters gene expression between CAVD aortic valve tissue and normal samples by immunohistochemistry, qPCR, and western blotting. VICs were cultured and treated with IL-21. Gene and protein expression levels of the osteoblastic markers ALP and Runx2, which can be blocked by specific JAK3 inhibitors and/or s ...[more]