Hypoxia regulates GR function through multiple mechanisms involving microRNAs 103 and 107.
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ABSTRACT:
SUBMITTER: Yang N
PROVIDER: S-EPMC7646191 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
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Hypoxia regulates GR function through multiple mechanisms involving microRNAs 103 and 107.
Yang Nan N Berry Andrew A Sauer Carolin C Baxter Matthew M Donaldson Ian J IJ Forbes Karen K Donn Rachelle R Matthews Laura L Ray David D
Molecular and cellular endocrinology 20200829
Glucocorticoids (Gcs) potently inhibit inflammation, and regulate liver energy metabolism, often acting in a hypoxic environment. We now show hypoxic conditions open a specific GR cistrome, and prevent access of GR to part of the normoxic GR cistrome. Motif analysis identified enrichment of KLF4 binding sites beneath those peaks of GR binding exclusive to normoxia, implicating KLF4 as a pioneer, or co-factor under these conditions. Hypoxia reduced KLF4 expression, however, knockdown of KLF4 did ...[more]
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