Ontology highlight
ABSTRACT:
SUBMITTER: Fan C
PROVIDER: S-EPMC7646840 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Fan Chen C El Andaloussi Samir S Lehto Taavi T Kong Kiat Whye KW Seow Yiqi Y
Molecular medicine reports 20200929 6
The exact mechanisms underlying hypertrophic scarring is yet to be fully understood. However, excessive collagen deposition by fibroblasts has been demonstrated to result in hypertrophic scar formation, and collagen synthesis in dermal fibroblasts is regulated by the transforming growth factor‑β1/Smad signaling pathway. In view of this, a Smad‑binding decoy was designed and its effects on hypertrophic scar‑derived human skin fibroblasts was evaluated. The results of the present study revealed th ...[more]