Ontology highlight
ABSTRACT:
SUBMITTER: Sebe A
PROVIDER: S-EPMC7647973 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Sebe Attila A Anliker Brigitte B Rau Juliane J Renner Matthias M
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 20201016 11
Adoptive T‑cell therapies are emerging tools to combat various human diseases. CAR‑T cells are approved and marketed as last line therapeutics in advanced B‑cell lymphomas and leukemias. TCR-engineered T cells are being evaluated in clinical trials for a variety of hematological and solid tumors. Genetically modified regulatory T cells, however, are still in the initial stages of clinical development for the induction of immune tolerance in various indications.Here we outline the general role of ...[more]