Ontology highlight
ABSTRACT:
SUBMITTER: Ichikawa A
PROVIDER: S-EPMC7648026 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Ichikawa Akihiro A Fujita Yu Y Hosaka Yusuke Y Kadota Tsukasa T Ito Akihiko A Yagishita Shigehiro S Watanabe Naoaki N Fujimoto Shota S Kawamoto Hironori H Saito Nayuta N Yoshida Masahiro M Hashimoto Mitsuo M Minagawa Shunsuke S Hara Hiromichi H Motoi Noriko N Yamamoto Yusuke Y Ochiya Takahiro T Araya Jun J Kuwano Kazuyoshi K
Cancer science 20200907 11
Chaperone-mediated autophagy (CMA) is a lysosomal degradation pathway of selective soluble proteins. Lysosome-associated membrane protein type 2a (LAMP2A) is the key receptor protein of CMA; downregulation of LAMP2A leads to CMA blockade. Although CMA activation has been involved in cancer growth, CMA status and functions in non-small cell lung cancer (NSCLC) by focusing on the roles in regulating chemosensitivity remain to be clarified. In this study, we found that LAMP2A expression is elevated ...[more]