Enduring neurobehavioral effects induced by microbiota depletion during the adolescent period.

ABSTRACT: The gut microbiota is an essential regulator of many aspects of host physiology. Disruption of gut microbial communities affects gut-brain communication which ultimately can manifest as changes in brain function and behaviour. Transient changes in gut microbial composition can be induced by various intrinsic and extrinsic factors, however, it is possible that enduring shifts in the microbiota composition can be achieved by perturbation at a timepoint when the gut microbiota has not fully matured or is generally unstable, such as during early life or ageing. In this study, we investigated the effects of 3-week microbiota depletion with antibiotic treatment during the adolescent period and in adulthood. Following a washout period to restore the gut microbiota, behavioural and molecular hallm

SUBMITTER: Lach G 

PROVIDER: S-EPMC7648059 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature