From deterministic to fuzzy decision-making in artificial cells.
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ABSTRACT:
SUBMITTER: Greiss F
PROVIDER: S-EPMC7648101 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
From deterministic to fuzzy decision-making in artificial cells.
Greiss Ferdinand F Daube Shirley S SS Noireaux Vincent V Bar-Ziv Roy R
Nature communications 20201106 1
Building autonomous artificial cells capable of homeostasis requires regulatory networks to gather information and make decisions that take time and cost energy. Decisions based on few molecules may be inaccurate but are cheap and fast. Realizing decision-making with a few molecules in artificial cells has remained a challenge. Here, we show decision-making by a bistable gene network in artificial cells with constant protein turnover. Reducing the number of gene copies from 10<sup>5</sup> to abo ...[more]
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