Differences in [¹⁸F]FDG uptake in BAT of UCP1 -/- and UCP1 +/+ during adrenergic stimulation of non-shivering thermogenesis.

ABSTRACT:

Background

Brown adipose tissue (BAT) is a fat tissue found in most mammals that helps regulate energy balance and core body temperature through a sympathetic process known as non-shivering thermogenesis. BAT activity is commonly detected and quantified in [¹⁸F]FDG positron emission tomography/computed tomography (PET/CT) scans, and radiotracer uptake in BAT during adrenergic stimulation is often used as a surrogate measure for identifying thermogenic activity in the tissue. BAT thermogenesis is believed to be contingent upon the expression of the protein UCP1, but conflicting results have been reported in the literature concerning [¹⁸F]FDG uptake within BAT of mice with and without UCP1. Differences in animal handling techniques such as feeding status, type o

SUBMITTER: McHugh CT 

PROVIDER: S-EPMC7648812 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature