Effect of acute noise trauma on the gene expression profile of the hippocampus.

ABSTRACT:

Background

This study aimed to investigate the changes in the expression of hippocampal genes upon acute noise exposure.

Methods

Three-week-old Sprague-Dawley rats were assigned to control (n = 15) and noise (n = 15) groups. White noise (2-20 kHz, 115 dB sound pressure level [SPL]) was delivered for 4 h per day for 3 days to the noise group. All rats were sacrificed on the last day of noise exposure, and gene expression in the hippocampus was analyzed using a microarray. Pathway analyses were conducted for genes that showed differential expression ≥ 1.5-fold and P ≤ 0.05 compared to the control group. The genes included in the putative pathways were measured using quantitative reverse transcription-polymerase chain reaction (qRT-PCR).

Results

Thirty-eight upregulated

SUBMITTER: Lee CH 

PROVIDER: S-EPMC7648995 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature