Ontology highlight
ABSTRACT:
SUBMITTER: Yoo KS
PROVIDER: S-EPMC7649087 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Yoo Ki-Seo KS Lee Kina K Lee Yong-Seok YS Oh Won-Jong WJ Kim Hyong Kyu HK
Experimental neurobiology 20201001 5
Guanine nucleotide exchange factors (GEFs) play multiple functional roles in neurons. In a previous study, we reported that <i>Arhgef4</i> (Rho guanine nucleotide exchange factor 4) functioned as a negative regulator of the excitatory synaptic function by sequestering postsynaptic density protein 95 (PSD-95). However, the role of <i>Arhgef4</i> in behavior has not been examined. We performed comprehensive behavioral tests in knockout (KO) mice to investigate of the effects of <i>Arhgef4</i> defi ...[more]