Ontology highlight
ABSTRACT:
SUBMITTER: Coste A
PROVIDER: S-EPMC7649363 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Coste Anouchka A Karagiannis George S GS Wang Yarong Y Xue Emily A EA Lin Yu Y Skobe Mihaela M Jones Joan G JG Oktay Maja H MH Condeelis John S JS Entenberg David D
Frontiers in oncology 20201026
In primary breast tumors, cancer cells hematogenously disseminate through doorways in the vasculature composed of three-cell complexes (known as Tumor MicroEnvironment of Metastasis) comprising a perivascular macrophage, a tumor cell overexpressing the actin-regulatory protein Mammalian Enabled (Mena), and an endothelial cell, all in direct physical contact. It has been previously shown that once tumor cells establish lymph node metastases in patients, TMEM doorways form in the metastatic tumor ...[more]