Ontology highlight
ABSTRACT:
SUBMITTER: van der Plas A
PROVIDER: S-EPMC7649435 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
van der Plas Angela A Pouly Sandrine S Blanc Nicolas N Haziza Christelle C de La Bourdonnaye Guillaume G Titz Bjorn B Hoeng Julia J Ivanov Nikolai V NV Taranu Brindusa B Heremans Annie A
Toxicology reports 20201029
<h4>Background</h4>Cigarette smoking induces cytochrome P450 1A2 (CYP1A2) expression and activity, while smoking cessation normalizes the levels of this enzyme. The aim of this publication is to summarize the data on CYP1A2 gene expression and activity in preclinical and clinical studies on the Tobacco Heating System (THS), currently marketed as <i>IQOS®</i> with <i>HEETs®</i>, and to summarize the potential effects on CYP1A2 to be expected upon switching to reduced-risk products (RRPs).<h4>Meth ...[more]