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Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases.

ABSTRACT: Aging is a major risk factor for numerous human pathologies, including cardiovascular, metabolic, musculoskeletal, and neurodegenerative conditions and various malignancies. While our understanding of aging is far from complete, recent advances suggest that targeting fundamental aging processes can delay, prevent, or alleviate age-related disorders. Cellular senescence is physiologically beneficial in several contexts, but it has causal roles in multiple chronic diseases. New studies have illustrated the promising feasibility and safety to selectively ablate senescent cells from tissues, a therapeutic modality that holds potential for treating multiple chronic pathologies and extending human healthspan. Here, we review molecular links between cellular senescence and age-associated complications and highlight novel therapeutic avenues that may be exploited to target senescent cells in future geriatric medicine.

SUBMITTER: Song S

PROVIDER: S-EPMC7649645 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases.

Song Shuling S Lam Eric W-F EW Tchkonia Tamara T Kirkland James L JL Sun Yu Y

Trends in biochemical sciences 20200406 7

Aging is a major risk factor for numerous human pathologies, including cardiovascular, metabolic, musculoskeletal, and neurodegenerative conditions and various malignancies. While our understanding of aging is far from complete, recent advances suggest that targeting fundamental aging processes can delay, prevent, or alleviate age-related disorders. Cellular senescence is physiologically beneficial in several contexts, but it has causal roles in multiple chronic diseases. New studies have illust ...[more]

PMID: 32531228

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