Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC7650218 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Li He H Dai Weixing W Xia Xi X Wang Renjie R Zhao Jing J Han Lingyu L Mo Shaobo S Xiang Wenqiang W Du Lin L Zhu Guangya G Xie Jingjing J Yu Jun J Liu Nan N Huang Mingzhu M Zhu Jidong J Cai Guoxiang G
Journal of hematology & oncology 20200903 1
Tumor metastasis accounts for the majority of cancer-related deaths; it is therefore important to develop preclinical models that faithfully recapitulate disease progression. Here, we generated paired organoids derived from primary tumors and matched liver metastases in the same colorectal cancer (CRC) patients. Despite the fact that paired organoids exhibit comparable gene expression and cell morphology, organoids from metastatic lesions demonstrate more aggressive phenotypes, tumorigenesis, an ...[more]