Dataset Information

Multi-Sacrificial Bonds Enhanced Double Network Hydrogel with High Toughness, Resilience, Damping, and Notch-Insensitivity.

ABSTRACT: The engineering applications of hydrogels are generally limited by the common problem of their softness and brittlness. In this study, a composite double network ionic hydrogel (CDN-gel) was obtained by the facile visible light triggered polymerization of acrylic acid (AA), polyvinyl alcohol (PVA), and hydrolyzed triethoxyvinylsilane (TEVS) and subsequent salt impregnation. The resulting CDN-gels exhibited high toughness, recovery ability, and notch-insensitivity. The tensile strength, fracture elongation, Young's modulus, and toughness of the CDN-gels reached up to ~21 MPa, ~700%, ~3.5 MPa, and ~48 M/m3, respectively. The residual strain at a strain of 200% was only ~25% after stretch-release of 1000 cycles. These properties will enable greater application of these hydrogel materials, especially for the fatigue resistance of tough hydrogels, as well as broaden their applications in damping.

SUBMITTER: Sun M

PROVIDER: S-EPMC7650701 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Multi-Sacrificial Bonds Enhanced Double Network Hydrogel with High Toughness, Resilience, Damping, and Notch-Insensitivity.

Sun Manxi M Qiu Jianhui J Lu Chunyin C Jin Shuping S Zhang Guohong G Sakai Eiichi E

Polymers 20201001 10

The engineering applications of hydrogels are generally limited by the common problem of their softness and brittlness. In this study, a composite double network ionic hydrogel (CDN-gel) was obtained by the facile visible light triggered polymerization of acrylic acid (AA), polyvinyl alcohol (PVA), and hydrolyzed triethoxyvinylsilane (TEVS) and subsequent salt impregnation. The resulting CDN-gels exhibited high toughness, recovery ability, and notch-insensitivity. The tensile strength, fracture ...[more]

PMID: 33019708

Similar Datasets

Project description:Small-caliber vascular grafts used in coronary artery bypass procedures typically fail due to the development of intimal hyperplasia or thrombosis. Our laboratory has developed a multilayered vascular graft with an electrospun polyurethane outer layer with improved compliance matching and a hydrogel inner layer that is both thromboresistant and promotes endothelialization. Initial in vivo studies showed that hydrogel particulates were dislodged from the hydrogel layer of the grafts during suturing. To address this problem, we developed and characterized a new hydrogel formulation that resists damage during suturing. Introduction of sacrificial, hydrogen bonds to poly(ethylene glycol)-based hydrogels via co-polymerization with n-vinyl pyrrolidone (NVP) increased the fracture energy as determined by single edge notch testing. This enhanced defect tolerance resulted in a hydrogel layer that was resistant to suture-induced damage with no dislodged particles observed. Importantly, the incorporation of NVP did not affect the thromboresistance, bioactivity, or biostability of the hydrogel layer. In addition to eliminating complications due to hydrogel particle generation in our multilayer graft design, this defect tolerant hydrogel formulation has broad potential use in many cardiovascular and soft tissue applications. STATEMENT OF SIGNIFICANCE:Small-caliber vascular grafts used in coronary artery bypass procedures typically fail due to development of intimal hyperplasia or thrombosis. Our laboratory has developed a multilayered vascular graft with an electrospun polyurethane outer layer with improved compliance matching and a hydrogel inner layer that is both thromboresistant and promotes endothelialization. However, hydrogel particulates were dislodged from the hydrogel layer during suturing in vivo. This work describes a hydrogel formulation based on poly(ethylene glycol) that is resistant to suture-induced damage. The introduction of sacrificial, hydrogen bonds by co-polymerization with n-vinyl pyrrolidone (NVP) resulted in an increase fracture energy without affecting the thromboresistance, bioactivity, or biostability. This defect-tolerant hydrogel formulation and the methodology to assess hydrogel defect tolerance has broad potential use in cardiovascular and soft tissue applications.

Dataset Information

Multi-Sacrificial Bonds Enhanced Double Network Hydrogel with High Toughness, Resilience, Damping, and Notch-Insensitivity.

Publications

Multi-Sacrificial Bonds Enhanced Double Network Hydrogel with High Toughness, Resilience, Damping, and Notch-Insensitivity.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets