Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Gonzalez R
PROVIDER: S-EPMC7650776 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
García-González Raúl R Morejón-García Patricia P Campillo-Marcos Ignacio I Salzano Marcella M Lazo Pedro A PA
Cancers 20201015 10
Dynamic remodeling of chromatin requires acetylation and methylation of histones, frequently affecting the same lysine residue. These alternative epigenetic modifications require the coordination of enzymes, writers and erasers, mediating them such as acetylases and deacetylases. In cells in G0/G1, DNA damage induced by doxorubicin causes an increase in histone H4K16ac, a marker of chromatin relaxation. In this context, we studied the role that VRK1, a chromatin kinase activated by DNA damage, p ...[more]