Dataset Information

Zoonotic infection with swine A/H1avN1 influenza virus in a child, Germany, June 2020.

ABSTRACT: A zoonotic A/sw/H1avN1 1C.2.2 influenza virus infection was detected in a German child that presented with influenza-like illness, including high fever. There was a history of close contact with pigs 3 days before symptom onset. The child recovered within 3 days. No other transmissions were observed. Serological investigations of the virus isolate revealed cross-reactions with ferret antisera against influenza A(H1N1)pdm09 virus, indicating a closer antigenic relationship with A(H1N1)pdm09 than with the former seasonal H1N1 viruses.

SUBMITTER: Durrwald R

PROVIDER: S-EPMC7651875 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Publications

Zoonotic infection with swine A/H1<sub>av</sub>N1 influenza virus in a child, Germany, June 2020.

Dürrwald Ralf R Wedde Marianne M Biere Barbara B Oh Djin-Ye DY Heßler-Klee Martina M Geidel Christian C Volmer Renate R Hauri Anja Maria AM Gerst Kai K Thürmer Andrea A Appelt Sandra S Reiche Janine J Duwe Susanne S Buda Silke S Wolff Thorsten T Haas Walter W

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20201001 42

A zoonotic A/sw/H1<sub>av</sub>N1 1C.2.2 influenza virus infection was detected in a German child that presented with influenza-like illness, including high fever. There was a history of close contact with pigs 3 days before symptom onset. The child recovered within 3 days. No other transmissions were observed. Serological investigations of the virus isolate revealed cross-reactions with ferret antisera against influenza A(H1N1)pdm09 virus, indicating a closer antigenic relationship with A(H1N1) ...[more]

PMID: 33094718

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Project description:MicroRNAs (miRNAs) repress the expression levels of genes by binding to mRNA transcripts, acting as master regulators of cellular processes. Differential expression of miRNAs has been linked to viral-associated diseases involving members of the hepacivirus, herpesvirus, and retrovirus families. In contrast, limited biological and molecular information has been reported on the potential role of cellular miRNAs in the lifecycle of influenza A viruses (infA). In this study, we hypothesize that elucidating the miRNA expression signatures induced by low-pathogenic swine-origin influenza A virus (S-OIV) pandemic H1N1 (2009) and highly pathogenic avian-origin (A-OIV) H7N7 (2003) infections could reveal temporal and strain-specific miRNA fingerprints during the viral lifecycle, shedding important insights into the potential role of cellular miRNAs in host-infA interactions. Using a microfluidic microarray platform, we profiled cellular miRNA expression in human A549 cells infected with S- and A-OIVs at multiple time-points during the viral lifecycle, including global gene expression profiling during S-OIV infection. Using target prediction and pathway enrichment analyses, we identified the key cellular pathways associated with the differentially expressed miRNAs and predicted mRNA targets during infA infection, including immune system, cell proliferation, apoptosis, cell cycle, and DNA replication and repair. By identifying the specific and dynamic molecular phenotypic changes (microRNAome) triggered by S- and A-OIV infection in human cells, we provide experimental evidence demonstrating a series of temporal- and strain-specific host molecular responses involving different combinatorial contributions of multiple cellular miRNAs. Our results also identify novel potential exosomal miRNA biomarkers associated with pandemic S-OIV and deadly A-OIV-host infection. Control (mock-infected) samples: 12, Infected samples: 6, for each time-point (0, 4, 8, 24, 48 and 72 hours post infection). Seven replicates for each miRNA were found on the microarray chips, for which the median has been retained. The experiment was performed in six replicates.

Dataset Information

Zoonotic infection with swine A/H1avN1 influenza virus in a child, Germany, June 2020.

Publications

Zoonotic infection with swine A/H1<sub>av</sub>N1 influenza virus in a child, Germany, June 2020.

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