Graph-theoretical formulation of the generalized epitope-based vaccine design problem.
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ABSTRACT:
SUBMITTER: Dorigatti E
PROVIDER: S-EPMC7652351 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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Graph-theoretical formulation of the generalized epitope-based vaccine design problem.
Dorigatti Emilio E Schubert Benjamin B
PLoS computational biology 20201023 10
Epitope-based vaccines have revolutionized vaccine research in the last decades. Due to their complex nature, bioinformatics plays a pivotal role in their development. However, existing algorithms address only specific parts of the design process or are unable to provide formal guarantees on the quality of the solution. We present a unifying formalism of the general epitope vaccine design problem that tackles all phases of the design process simultaneously and combines all prevalent design princ ...[more]
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