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Visualization of sodium dynamics in the kidney by magnetic resonance imaging in a multi-site study.

ABSTRACT: Sodium magnetic resonance imaging (MRI) is a powerful, non-invasive technique to assess sodium distribution within the kidney. Here we undertook pre-clinical and clinical studies to quantify the corticomedullary sodium gradient in healthy individuals and in a porcine model of diuresis. The results demonstrated that sodium MRI could detect spatial differences in sodium biodistribution across the kidney. The sodium gradient of the kidney changed significantly after diuresis in the pig model and was independent of blood electrolyte measurements. Thus, rapid sodium MRI can be used to dynamically quantify sodium biodistribution in the porcine and human kidney.

SUBMITTER: Grist JT 

PROVIDER: S-EPMC7652549 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Visualization of sodium dynamics in the kidney by magnetic resonance imaging in a multi-site study.

Grist James T JT   Riemer Frank F   Hansen Esben S S ESS   Tougaard Rasmus S RS   McLean Mary A MA   Kaggie Joshua J   Bøgh Nikolaj N   Graves Martin J MJ   Gallagher Ferdia A FA   Laustsen Christoffer C  

Kidney international 20200622 5

Sodium magnetic resonance imaging (MRI) is a powerful, non-invasive technique to assess sodium distribution within the kidney. Here we undertook pre-clinical and clinical studies to quantify the corticomedullary sodium gradient in healthy individuals and in a porcine model of diuresis. The results demonstrated that sodium MRI could detect spatial differences in sodium biodistribution across the kidney. The sodium gradient of the kidney changed significantly after diuresis in the pig model and wa  ...[more]

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