GENetic characteristics and REsponse to lipid-lowering therapy in familial hypercholesterolemia: GENRE-FH study.
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ABSTRACT:
SUBMITTER: Kim H
PROVIDER: S-EPMC7653043 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
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GENetic characteristics and REsponse to lipid-lowering therapy in familial hypercholesterolemia: GENRE-FH study.
Kim Hyoeun H Lee Chan Joo CJ Pak Hayeon H Kim Doo-Il DI Rhee Moo-Yong MY Lee Byoung Kwon BK Ahn Youngkeun Y Cho Byung-Ryul BR Woo Jeong-Taek JT Hur Seung-Ho SH Jeong Jin-Ok JO Lee Ji Hyun JH Lee Sang-Hak SH
Scientific reports 20201109 1
Among the 146 patients enrolled in the Korean FH registry, 83 patients who had undergone appropriate LLT escalation and were followed-up for ≥ 6 months were analyzed for pathogenic variants (PVs). The achieved percentage of expected low-density lipoprotein-cholesterol (LDL-C) reduction (primary variable) and achievement rates of LDL-C < 70 mg/dL were assessed. The correlations between the treatment response and the characteristics of PVs, and the weighted 4 SNP-based score were evaluated. The pr ...[more]
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