Ontology highlight
ABSTRACT:
SUBMITTER: Tan AH
PROVIDER: S-EPMC7653077 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Tan Andy Hee-Meng AH Tso Gloria Hoi Wan GHW Zhang Biyan B Teo Pei-Yun PY Ou Xijun X Ng Sze-Wai SW Wong Alex Xing Fah AXF Tan Sean Jing Xiang SJX Sanny Arleen A Kim Susana Soo-Yeon SS Lee Alison P AP Xu Shengli S Lam Kong-Peng KP
iScience 20201022 11
TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) plays critical roles in B cells by promoting immunoglobulin class switching and plasma cell survival. However, its expression and function in T cells remain controversial. We show here that TACI expression can be strongly induced in murine CD4<sup>+</sup> T cells <i>in vitro</i> by cytokines responsible for T<sub>H</sub>17 but not T<sub>H</sub>1 or T<sub>H</sub>2 differentiation. Frequencies and numbers of T<s ...[more]