Ontology highlight
ABSTRACT:
SUBMITTER: Jennings E
PROVIDER: S-EPMC7653457 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Jennings Emma E Elliot Thomas A E TAE Thawait Natasha N Kanabar Shivani S Yam-Puc Juan Carlos JC Ono Masahiro M Toellner Kai-Michael KM Wraith David C DC Anderson Graham G Bending David D
Cell reports 20201101 5
Nr4a receptors are activated by T cell receptor (TCR) signaling and play key roles in T cell differentiation. Which TCR signaling pathways regulate Nr4a receptors and their sensitivities to TCR signal strength and duration remains unclear. Using Nr4a1/Nur77-GFP and Nr4a3-Timer of cell kinetics and activity (Tocky) mice, we elucidate the signaling pathways governing Nr4a receptor expression. We reveal that Nr4a1-Nr4a3 are Src family kinase dependent. Moreover, Nr4a2 and Nr4a3 are attenuated by ca ...[more]