Gene signatures of m5C regulators may predict prognoses of patients with head and neck squamous cell carcinoma.

ABSTRACT:

Background

Head and neck squamous cell carcinoma (HNSCC) is the fifth most common malignancy in the world. The 5-methylcytosine (m5C) plays vital roles in pathological conditions, such as cancer.

Methods

This study investigated The Cancer Genome Atlas (TCGA) database for patients with HNSCC. We characterized the mutations and copy number variations (CNVs) in m5C-regulatory genes, in addition to analyzing their mRNA expressions. Gene set enrichment analysis (GSEA) and protein-protein interaction (PPI) analyses were used to explore relevant functional annotations of m5C-regulatory genes.

Results

Alterations in m5C-regulatory genes were closely associated with patient clinicopathological characteristics. The expression of ten m5C-regulatory genes was significantly correl

SUBMITTER: Xue M 

PROVIDER: S-EPMC7653571 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature