Egr-1 mediates low-dose arecoline induced human oral mucosa fibroblast proliferation via transactivation of Wnt5a expression.
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ABSTRACT:
SUBMITTER: Chen Q
PROVIDER: S-EPMC7653895 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
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Egr-1 mediates low-dose arecoline induced human oral mucosa fibroblast proliferation via transactivation of Wnt5a expression.
Chen Qiang Q Jiao Jiuyang J Wang Youyuan Y Mai Zhihui Z Ren Jing J He Sijie S Li Xiaolan X Chen Zheng Z
BMC molecular and cell biology 20201110 1
<h4>Background</h4>Arecoline is an alkaloid natural product found in the areca nut that can induce oral submucous fibrosis and subsequent development of cancer. However, numerous studies have shown that arecoline may inhibit fibroblast proliferation and prevent collagen synthesis.<h4>Results</h4>High doses of arecoline (> 32 μg/ml) could inhibit human oral fibroblast proliferation, while low doses of arecoline (< 16 μg/ml) could promote the proliferation of human oral fibroblasts. Wnt5a was foun ...[more]
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