Ontology highlight
ABSTRACT:
SUBMITTER: Raman K
PROVIDER: S-EPMC7654310 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Raman Karthik K Nguyen Thao Kim Nu TK Kuberan Balagurunathan B
FEBS letters 20111002 21
Several biologically important growth factor-heparan sulfate (HS) interactions are regulated by HS sulfation patterns. However, the biogenesis of these combinatorial sulfation patterns is largely unknown. N-Deacetylase/N-sulfotrasferase (NDST) converts N-acetyl-d-glucosamine residues to N-sulfo-d-glucosamine residues. This enzyme is suggested to be a gateway enzyme because N-sulfation dictates the final HS sulfation pattern. It is known that O-sulfation blocks C5-epimerase, which acts immediatel ...[more]