Cross-species models of attention-deficit/hyperactivity disorder and autism spectrum disorder: lessons from CNTNAP2, ADGRL3, and PARK2.
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ABSTRACT:
SUBMITTER: Dalla Vecchia E
PROVIDER: S-EPMC7654943 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
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Cross-species models of attention-deficit/hyperactivity disorder and autism spectrum disorder: lessons from CNTNAP2, ADGRL3, and PARK2.
Dalla Vecchia Elisa E Mortimer Niall N Palladino Viola S VS Kittel-Schneider Sarah S Lesch Klaus-Peter KP Reif Andreas A Schenck Annette A Norton William H J WHJ
Psychiatric genetics 20190201 1
Animal and cellular models are essential tools for all areas of biological research including neuroscience. Model systems can also be used to investigate the pathophysiology of psychiatric disorders such as attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). In this review, we provide a summary of animal and cellular models for three genes linked to ADHD and ASD in human patients - CNTNAP2, ADGRL3, and PARK2. We also highlight the strengths and weaknesses of each ...[more]
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