SNCA Rep1 microsatellite length influences non-motor symptoms in early Parkinson's disease.
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ABSTRACT:
SUBMITTER: Yong AC
PROVIDER: S-EPMC7655210 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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<i>SNCA</i> Rep1 microsatellite length influences non-motor symptoms in early Parkinson's disease.
Yong Alisa Cw AC Tan Yi Jayne YJ Zhao Yi Y Lu Zhonghao Z Ng Ebonne Yl EY Ng Samuel Ye SY Chia Nicole Sy NS Choi Xinyi X Heng Dede D Neo Shermyn S Xu Zheyu Z Tay Kay Yaw KY Au Wing Lok WL Tan Eng-King EK Tan Louis Cs LC Ng Adeline Sl AS
Aging 20201020 20
Long alpha-synuclein gene <i>(SNCA)</i> promoter (Rep1) allele-carriers are linked to higher risk for Parkinson's disease (PD) and faster motor progression. Non-motor symptoms including autonomic, neuropsychiatric, and sleep disorders are common in PD. However, the relationship between <i>SNCA</i> Rep1 microsatellite lengths and non-motor symptoms in early PD remains to be elucidated. 171 consecutive early PD patients were recruited from tertiary clinics and genotyped for Rep1. Multivariable reg ...[more]
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