Ontology highlight
ABSTRACT:
SUBMITTER: Kim YC
PROVIDER: S-EPMC7655548 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Nature biomedical engineering 20200907 11
Eye-drop formulations should hold as high a concentration of soluble drug in contact with ocular epithelium for as long as possible. However, eye tears and frequent blinking limit drug retention on the ocular surface, and gelling drops typically form clumps that blur vision. Here, we describe a gelling hypotonic solution containing a low concentration of a thermosensitive triblock copolymer for extended ocular drug delivery. On topical application, the hypotonic formulation forms a highly unifor ...[more]