Mitochondria interaction networks show altered topological patterns in Parkinson's disease.
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ABSTRACT:
SUBMITTER: Zanin M
PROVIDER: S-EPMC7655803 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Mitochondria interaction networks show altered topological patterns in Parkinson's disease.
Zanin Massimiliano M Santos Bruno F R BFR Antony Paul M A PMA Berenguer-Escuder Clara C Larsen Simone B SB Hanss Zoé Z Barbuti Peter A PA Baumuratov Aidos S AS Grossmann Dajana D Capelle Christophe M CM Weber Joseph J Balling Rudi R Ollert Markus M Krüger Rejko R Diederich Nico J NJ He Feng Q FQ
NPJ systems biology and applications 20201110 1
Mitochondrial dysfunction is linked to pathogenesis of Parkinson's disease (PD). However, individual mitochondria-based analyses do not show a uniform feature in PD patients. Since mitochondria interact with each other, we hypothesize that PD-related features might exist in topological patterns of mitochondria interaction networks (MINs). Here we show that MINs formed nonclassical scale-free supernetworks in colonic ganglia both from healthy controls and PD patients; however, altered network top ...[more]
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