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Apolipoprotein M inhibits proliferation and migration of larynx carcinoma cells.

ABSTRACT: Prior studies have shown that apolipoprotein M (APOM) is involved in the development of some cancers. Here we investigated the effects of APOM on larynx cancer (LC). 20 patients with vocal cord polyps and 18 patients with LC were included in this study. The protein and mRNA levels of the samples were analysed using the Wes-ProteinSimple system (or traditional Western blot) and PCR technology, respectively. APOM protein level in cancer tissues was lower than that in paracarcinomatous (P?=?0.0003) and polyp tissues (P??0.05). In summary, APOM inhibits the proliferation and migration of LC cells, but may not be related to VDR, NFE2L3 and MMP-10, which needs further study.

SUBMITTER: Xue H

PROVIDER: S-EPMC7655836 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Apolipoprotein M inhibits proliferation and migration of larynx carcinoma cells.

Xue Haixiang H Yu Miaomei M Zhou Ying Y Zhang Jun J Mu Qinfeng Q Chen Tongbing T Luo Guanghua G Liu Jisheng J

Scientific reports 20201110 1

Prior studies have shown that apolipoprotein M (APOM) is involved in the development of some cancers. Here we investigated the effects of APOM on larynx cancer (LC). 20 patients with vocal cord polyps and 18 patients with LC were included in this study. The protein and mRNA levels of the samples were analysed using the Wes-ProteinSimple system (or traditional Western blot) and PCR technology, respectively. APOM protein level in cancer tissues was lower than that in paracarcinomatous (P = 0.0003) ...[more]

PMID: 33173129

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