Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Huynh K
PROVIDER: S-EPMC7655942 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer's disease.
Huynh Kevin K Lim Wei Ling Florence WLF Giles Corey C Jayawardana Kaushala S KS Salim Agus A Mellett Natalie A NA Smith Adam Alexander T AAT Olshansky Gavriel G Drew Brian G BG Chatterjee Pratishtha P Martins Ian I Laws Simon M SM Bush Ashley I AI Rowe Christopher C CC Villemagne Victor L VL Ames David D Masters Colin L CL Arnold Matthias M Nho Kwangsik K Saykin Andrew J AJ Baillie Rebecca R Han Xianlin X Kaddurah-Daouk Rima R Martins Ralph N RN Meikle Peter J PJ
Nature communications 20201110 1
Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer's disease (AD). Lipids are complex molecules comprising many isomeric and isobaric species, necessitating detailed analysis to enable interpretation of biological significance. Our expanded targeted lipidomics platform (569 species across 32 classes) allows for detailed lipid separation and characterisation. In this study we examined peripheral samples of two cohorts (AIBL, n = 1112 and ADNI, n = 800). W ...[more]
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