Aging Impacts the Overall Connectivity Strength of Regions Critical for Information Transfer Among Brain Networks.

ABSTRACT: Recent studies have demonstrated that connector hubs, regions considered critical for the flow of information across neural systems, are mostly involved in neurodegenerative dementia. Considering that aging can significantly affect the brain's intrinsic connectivity, identifying aging's impact on these regions' overall connection strength is important to differentiate changes associated with healthy aging from neurodegenerative disorders. Using resting state functional magnetic resonance imaging data from a carefully selected cohort of 175 healthy volunteers aging from 21 to 86 years old, we computed an intrinsic connectivity contrast (ICC) metric, which quantifies a region's overall connectivity strength, for whole brain, short-range, and long-range connections and examined age-related ch

SUBMITTER: Bagarinao E 

PROVIDER: S-EPMC7655963 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature