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Quantitative informant- and self-reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ?4.


ABSTRACT: Introduction:Amyloid beta (A?) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict A? positron emission tomography (PET) outcome in cognitively unimpaired middle-aged individuals. Methods:A total of 261 participants from the ALFA+ study underwent [18F]flutemetamol PET and Subjective Cognitive Decline Questionnaire (SCD-Q) concurrently, and 3 years before scan. We used logistic regressions to evaluate the ability of SCD-Q scores (self and informant) to predict A? PET visual read, and repeated analysis of variance to assess whether changes in SCD-Q scores relate to A? status. Results:Self-perception of decline in memory (odds ratio [OR] = 1.2), and informant perception of executive decline (OR = 1.6), increased the probability of a positive scan. Informant reports 3 years before scanning predicted A? PET outcome. Longitudinal increase of self-reported executive decline was predictive of A? in women (P = .003). Discussion:Subjective reports of cognitive decline are useful to predict A? and may improve recruitment strategies.

SUBMITTER: Sanchez-Benavides G 

PROVIDER: S-EPMC7656171 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Quantitative informant- and self-reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and <i>APOE</i> <i>ε4</i>.

Sánchez-Benavides Gonzalo G   Salvadó Gemma G   Arenaza-Urquijo Eider M EM   Grau-Rivera Oriol O   Suárez-Calvet Marc M   Milà-Alomà Marta M   González-de-Echávarri José María JM   Minguillon Carolina C   Crous-Bou Marta M   Niñerola-Baizán Aida A   Perissinotti Andrés A   Gispert Juan Domingo JD   Molinuevo José Luis JL  

Alzheimer's & dementia (Amsterdam, Netherlands) 20201111 1


<h4>Introduction</h4>Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) outcome in cognitively unimpaired middle-aged individuals.<h4>Methods</h4>A total of 261 participants from the ALFA+ study underwent [<sup>18</sup>F]flutemetamol PET and Subjective Cognitive Decline Questionnaire (SCD-Q) concurrently, and 3 years before scan. We used lo  ...[more]

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