Ontology highlight
ABSTRACT:
SUBMITTER: Siwek W
PROVIDER: S-EPMC7657446 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Molecular cell 20201026 3
Cytokine activation of cells induces gene networks involved in inflammation and immunity. Transient gene activation can have a lasting effect even in the absence of ongoing transcription, known as long-term transcriptional memory. Here we explore the nature of the establishment and maintenance of interferon γ (IFNγ)-induced priming of human cells. We find that, although ongoing transcription and local chromatin signatures are short-lived, the IFNγ-primed state stably propagates through at least ...[more]