Inflammation, reward circuitry and symptoms of anhedonia and PTSD in trauma-exposed women.
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ABSTRACT:
SUBMITTER: Mehta ND
PROVIDER: S-EPMC7657453 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Inflammation, reward circuitry and symptoms of anhedonia and PTSD in trauma-exposed women.
Mehta Neeti D ND Stevens Jennifer S JS Li Zhihao Z Gillespie Charles F CF Fani Negar N Michopoulos Vasiliki V Felger Jennifer C JC
Social cognitive and affective neuroscience 20201101 10
Trauma exposure is associated with increased inflammatory biomarkers (e.g. C-reactive protein [CRP] and cytokines), and inflammation has been shown to impact corticostriatal reward circuitry and increase anhedonia-related symptoms. We examined resting-state functional MRI in a high-trauma inner-city population of African-American women (n = 56), who reported on average five different types of trauma exposures, to investigate whether inflammation correlated with functional connectivity (FC) in co ...[more]
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