Ontology highlight
ABSTRACT:
SUBMITTER: Lahue KG
PROVIDER: S-EPMC7657953 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Lahue Karolyn G KG Lara Montana K MK Linton Alisha A AA Lavoie Brigitte B Fang Qian Q McGill Mahalia M MM Crothers Jessica W JW Teuscher Cory C Mawe Gary M GM Tyler Anna L AL Mahoney J Matthew JM Krementsov Dimitry N DN
Genes and immunity 20200826 5
Inflammatory bowel disease (IBD) is a complex disorder that imposes a growing health burden. Multiple genetic associations have been identified in IBD, but the mechanisms underlying many of these associations are poorly understood. Animal models are needed to bridge this gap, but conventional laboratory mouse strains lack the genetic diversity of human populations. To more accurately model human genetic diversity, we utilized a panel of chromosome (Chr) substitution strains, carrying chromosomes ...[more]