Human-Recombinant-Elastin-Based Bioinks for 3D Bioprinting of Vascularized Soft Tissues.

ABSTRACT: Bioprinting has emerged as an advanced method for fabricating complex 3D tissues. Despite the tremendous potential of 3D bioprinting, there are several drawbacks of current bioinks and printing methodologies that limit  the ability to print elastic and highly vascularized tissues. In particular, fabrication of complex biomimetic structure that are entirely based on 3D bioprinting is still challenging primarily due to the lack of suitable bioinks with high printability, biocompatibility, biomimicry, and proper mechanical properties. To address these shortcomings, in this work the use of recombinant human tropoelastin as a highly biocompatible and elastic bioink for 3D printing of complex soft tissues is demonstrated. As proof of the concept, vascularized cardiac constructs are bioprinted an

SUBMITTER: Lee S 

PROVIDER: S-EPMC7658039 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature