Ontology highlight
ABSTRACT:
SUBMITTER: Nagarkatti R
PROVIDER: S-EPMC7658208 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Nagarkatti Rana R Acosta David D Acharyya Nirmallya N de Araujo Fernanda Fortes FF Elói-Santos Silvana Maria SM Martins-Filho Olindo Assis OA Teixeira-Carvalho Andréa A Debrabant Alain A
Scientific reports 20201111 1
Chagas drug discovery has been hampered by a lack of validated assays to establish treatment efficacy in pre-clinical animal models and in patients infected with T. cruzi. Reduced levels of parasite secreted antigens in the blood of infected hosts could be used to demonstrate treatment efficacy. A published proteomic study of parasite secreted antigens identified the hypothetical protein Tc_5171 as a secreted antigen. In this report, we developed Tc_5171 specific antibodies and showed that the n ...[more]