Ontology highlight
ABSTRACT:
SUBMITTER: Dutta NK
PROVIDER: S-EPMC7658223 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Dutta Noton K NK Tornheim Jeffrey A JA Fukutani Kiyoshi F KF Paradkar Mandar M Tiburcio Rafael T RT Kinikar Aarti A Valvi Chhaya C Kulkarni Vandana V Pradhan Neeta N Shivakumar Shri Vijay Bala Yogendra SVBY Kagal Anju A Gupte Akshay A Gupte Nikhil N Mave Vidya V Gupta Amita A Andrade Bruno B BB Karakousis Petros C PC
Scientific reports 20201111 1
Pediatric tuberculosis (TB) remains a major global health problem. Improved pediatric diagnostics using readily available biosources are urgently needed. We used liquid chromatography-mass spectrometry to analyze plasma metabolite profiles of Indian children with active TB (n = 16) and age- and sex-matched, Mycobacterium tuberculosis-exposed but uninfected household contacts (n = 32). Metabolomic data were integrated with whole blood transcriptomic data for each participant at diagnosis and thro ...[more]