MiR-30c-1* promotes natural killer cell cytotoxicity against human hepatoma cells by targeting the transcription factor HMBOX1.
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ABSTRACT:
SUBMITTER: Gong J
PROVIDER: S-EPMC7659379 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
miR-30c-1* promotes natural killer cell cytotoxicity against human hepatoma cells by targeting the transcription factor HMBOX1.
Gong Jiuyu J Liu Rongrong R Zhuang Ran R Zhang Yun Y Fang Liang L Xu Zhuwei Z Jin Liang L Wang Tao T Song Chaojun C Yang Kun K Wei Yuying Y Yang Angang A Jin Boquan B Chen Lihua L
Cancer science 20120213 4
Natural killer (NK) cells play a critical role in antitumor immunity, and the activation of NK cells is regulated by a series of NK cell receptors. Here, we show that crosslinking CD226, an important NK cell receptor, with the anti-CD226 mAb LeoA1 on NKL cells, regulated the expression of several microRNA and transmembrane tumor necrosis factor-α. Among them, miR-30c-1(*) was noticed because overexpression of miR-30c-1(*) triggered upregulation of transmembrane tumor necrosis factor-α expression ...[more]
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