A Potential Role for Stress-Induced Microbial Alterations in IgA-Associated Irritable Bowel Syndrome with Diarrhea.
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ABSTRACT:
SUBMITTER: Rengarajan S
PROVIDER: S-EPMC7659537 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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A Potential Role for Stress-Induced Microbial Alterations in IgA-Associated Irritable Bowel Syndrome with Diarrhea.
Rengarajan Sunaina S Knoop Kathryn A KA Rengarajan Arvind A Chai Jiani N JN Grajales-Reyes Jose G JG Samineni Vijay K VK Russler-Germain Emilie V EV Ranganathan Prabha P Fasano Alessio A Sayuk Gregory S GS Gereau Robert W RW Kau Andrew L AL Knights Dan D Kashyap Purna C PC Ciorba Matthew A MA Newberry Rodney D RD Hsieh Chyi-Song CS
Cell reports. Medicine 20201001 7
Stress is a known trigger for flares of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS); however, this process is not well understood. Here, we find that restraint stress in mice leads to signs of diarrhea, fecal dysbiosis, and a barrier defect via the opening of goblet-cell associated passages. Notably, stress increases host immunity to gut bacteria as assessed by immunoglobulin A (IgA)-bound gut bacteria. Stress-induced microbial changes are necessary and sufficient to elic ...[more]
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